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Stk39 Antibody

CAT: 0223-4855-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4855-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Stk39 Antibody: The serine/threonine kinase Stk39 belongs to the STE20 family, a group of kinases that are known to interact with inflammation-related kinases (such as p38, JNK, NKCC1, PKC-theta, WNK and MLCK), and with transcription factor AP-1. The STE 20 family is involved in diverse biological phenomena, including cell differentiation, cell transformation/ proliferation, cytoskeleton rearrangement, and the regulation of ion transporters. STK39 contains an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain and is abundantly expressed in the brain. STK39 is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled co-transporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Recent studies show that STK39 tend to be a novel candidate gene for autism and hypertension.
NCBI Gene ID
27347
Swiss Prot
Q9UEW8
Accession Number
NP_037365
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Stk39 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1220 - SK-N-SH Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (100%), Pig: (95%)
Buffer
Stk39 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Stk39 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
STK39
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
NCBI Organism
Homo sapiens
Background Reference 01
Johnston AM, Nacelli G, Gonzales LJ, et al. SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene2000; 19:4290-7.
Background Reference 02
Li Y, Hu J, Vita R, et al. SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway. EMBO J.2004; 23:1112-22.
Background Reference 03
Gagnon KB, England R, and Delpire E. Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter. Mol. Cell Biol.2006; 26:689-98.
Background Reference 04
Dan I, Watanabe NM, and Kasumi A. The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell. Biol.2001; 11:220-30.
Other Product Names
Stk39 Antibody: DCHT, PASK, SPAK, DCHT, Ste-20-related kinase
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
115430252
Physical Properties
Liquid

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