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ADRBK1 Antibody

CAT: 0223-62-582Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-582Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Beta-adrenergic receptor kinase (ADRBK1), also known as GRK2, phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. ADRBK1 is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by the beta-AR kinase (beta-ARK1), an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
NCBI Gene ID
156
Swiss Prot
P25098
Accession Number
P25098
Host
Rabbit
Reactivity
Human
Immunogen
This ADRBK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 633-660 amino acids from the C-terminal region of human ADRBK1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
80 kDa
Fragment
Rabbit Ig
Symbol
ADRBK1
NCBI Official Name
Beta-adrenergic receptor kinase 1
NCBI Organism
Homo sapiens
Background Reference 01
Li, J., et al., J. Biol. Chem. 278 (32) :30219-30226 (2003) .
Background Reference 02
Wan, K.F., et al., J. Biol. Chem. 278 (20) :18658-18663 (2003) .
Background Reference 03
Yang, X.L., et al., World J. Gastroenterol. 9 (4) :800-803 (2003) .
Background Reference 04
Hagen, S.A., et al., Anesthesiology 98 (2) :343-348 (2003) .
Other Product Names
Beta-adrenergic receptor kinase 1, Beta-ARK-1, G-protein coupled receptor kinase 2, ADRBK1, BARK, BARK1, GRK2
Tested Applications
WB, IHC-P
Protein ID
126302521
Physical Properties
Liquid

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