KIR2DS3 Antibody

• Background:

  Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC) . The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) . The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

• NCBI Gene ID:

  3808

• Swiss Prot:

  Q14952

• Accession Number:

  Q14952

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This KIR2DS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-295 amino acids from the C-terminal region of human KIR2DS3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  34 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  KIR2DS3

• NCBI Official Name:

  Killer cell immunoglobulin-like receptor 2DS3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Valiante, N.M., et al. Immunity 7 (6) :739-751 (1997)

• Background Reference 02:

  Bottino, C., et al. Eur. J. Immunol. 26 (8) :1816-1824 (1996)

• Background Reference 03:

  Dohring, C., et al. Immunogenetics 44 (3) :227-230 (1996)

• Background Reference 04:

  Wagtmann, N., et al. Immunity 2 (5) :439-449 (1995)

• Other Product Names:

  Killer cell immunoglobulin-like receptor 2DS3, MHC class I NK cell receptor, Natural killer-associated transcript 7, NKAT-7, KIR2DS3, NKAT7

• Tested Applications:

  WB, IHC-P, Flow

• Physical Properties:

  Liquid