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KIR2DS3 Antibody

CAT: 0223-62-042Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-042Size:400 µL
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Background
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC) . The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) . The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
NCBI Gene ID
3808
Swiss Prot
Q14952
Accession Number
Q14952
Host
Rabbit
Reactivity
Human
Immunogen
This KIR2DS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-295 amino acids from the C-terminal region of human KIR2DS3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
34 kDa
Fragment
Rabbit Ig
Symbol
KIR2DS3
NCBI Official Name
Killer cell immunoglobulin-like receptor 2DS3
NCBI Organism
Homo sapiens
Background Reference 01
Valiante, N.M., et al. Immunity 7 (6) :739-751 (1997)
Background Reference 02
Bottino, C., et al. Eur. J. Immunol. 26 (8) :1816-1824 (1996)
Background Reference 03
Dohring, C., et al. Immunogenetics 44 (3) :227-230 (1996)
Background Reference 04
Wagtmann, N., et al. Immunity 2 (5) :439-449 (1995)
Other Product Names
Killer cell immunoglobulin-like receptor 2DS3, MHC class I NK cell receptor, Natural killer-associated transcript 7, NKAT-7, KIR2DS3, NKAT7
Tested Applications
WB, IHC-P, Flow
Physical Properties
Liquid

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