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KIR2DS1 Antibody

CAT: 0223-57-341Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-341Size:400 µL
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Background
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC) . The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) . The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
NCBI Gene ID
3806
Swiss Prot
Q14954
Accession Number
Q14954
Host
Rabbit
Reactivity
Human
Immunogen
This KIR2DS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the Central region of human KIR2DS1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
34 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
KIR2DS1
NCBI Official Name
Killer cell immunoglobulin-like receptor 2DS1
NCBI Organism
Homo sapiens
Background Reference 01
Wauquier, N., et al. Immunogenetics 62 (11-12), 767-771 (2010) :
Background Reference 02
Jiao, Y.L., et al. J. Clin. Immunol. 30 (6) :840-844 (2010)
Background Reference 03
Zhu, B.F., et al. Hum. Immunol. 71 (11) :1116-1123 (2010)
Background Reference 04
Velickovic, M., et al. Tissue Antigens 76 (4) :325-330 (2010)
Other Product Names
Killer cell immunoglobulin-like receptor 2DS1, CD158 antigen-like family member H, MHC class I NK cell receptor Eb6 ActI, CD158h, KIR2DS1, CD158H
Tested Applications
WB
Protein ID
13124324
Physical Properties
Liquid

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