FOXP2 Antibody

• Background:

  FOXP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.

• NCBI Gene ID:

  93986

• Swiss Prot:

  O15409

• Accession Number:

  O15409

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This FOXP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 657-684 amino acids from the C-terminal region of human FOXP2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  80 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  FOXP2

• NCBI Official Name:

  Forkhead box protein P2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lai, C.S., et al. Nature 413 (6855) :519-523 (2001) Lai, C.S., et al. Am. J. Hum. Genet. 67 (2) :357-368 (2000) Margolis, R.L., et al. Hum. Genet. 100 (1) :114-122 (1997) Hurst, J.A., et al. Dev Med Child Neurol 32 (4) :352-355 (1990)

• Other Product Names:

  Forkhead box protein P2, CAG repeat protein 44, Trinucleotide repeat-containing gene 10 protein, FOXP2, CAGH44, TNRC10

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid