IKZF3 Antibody

• Background:

  This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.

• NCBI Gene ID:

  22806

• Swiss Prot:

  Q9UKT9

• Accession Number:

  Q9UKT9

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This IKZF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the Central region of human IKZF3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  58 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  IKZF3

• NCBI Official Name:

  Zinc finger protein Aiolos

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Billot, K., et al. Leuk. Res. 34 (3) :289-293 (2010)

• Background Reference 02:

  Hirschfield, G.M., et al. N. Engl. J. Med. 360 (24) :2544-2555 (2009)

• Background Reference 03:

  Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18 (1) :255-259 (2009)

• Background Reference 04:

  Vieira, A.R., et al. Genet. Med. 10 (9) :668-674 (2008)

• Other Product Names:

  Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3

• Tested Applications:

  WB

• Protein ID:

  212276437

• Physical Properties:

  Liquid