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IKZF3 Antibody

CAT: 0223-61-999Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-999Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.
NCBI Gene ID
22806
Swiss Prot
Q9UKT9
Accession Number
Q9UKT9
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This IKZF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-103 amino acids from the Central region of human IKZF3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
58 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
IKZF3
NCBI Official Name
Zinc finger protein Aiolos
NCBI Organism
Homo sapiens
Background Reference 01
Billot, K., et al. Leuk. Res. 34 (3) :289-293 (2010)
Background Reference 02
Hirschfield, G.M., et al. N. Engl. J. Med. 360 (24) :2544-2555 (2009)
Background Reference 03
Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18 (1) :255-259 (2009)
Background Reference 04
Vieira, A.R., et al. Genet. Med. 10 (9) :668-674 (2008)
Other Product Names
Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3
Tested Applications
WB
Protein ID
212276437
Physical Properties
Liquid

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