SRD5A2 Antibody

CAT: 0223-61-971Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-61-971Size:400 µL
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Background
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH) .
NCBI Gene ID
6716
Swiss Prot
P31213
Accession Number
P31213
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This SRD5A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the Central region of human SRD5A2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
28 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SRD5A2
NCBI Official Name
3-oxo-5-alpha-steroid 4-dehydrogenase 2
NCBI Organism
Homo sapiens
Background Reference 01
Thigpen, A.E., et al. N. Engl. J. Med. 327 (17) :1216-1219 (1992)
Background Reference 02
Thigpen, A.E., et al. J. Clin. Invest. 90 (3) :799-809 (1992)
Background Reference 03
Labrie, F., et al. Endocrinology 131 (3) :1571-1573 (1992)
Background Reference 04
Andersson, S., et al. Nature 354 (6349) :159-161 (1991)
Other Product Names
3-oxo-5-alpha-steroid 4-dehydrogenase 2, 5 alpha-SR2, SR type 2, Steroid 5-alpha-reductase 2, S5AR 2, Type II 5-alpha reductase, SRD5A2
Tested Applications
WB
Protein ID
401056
Physical Properties
Liquid

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