CD49e Antibody

• Background:

  CD49e belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein is the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

• NCBI Gene ID:

  3678

• Swiss Prot:

  P08648

• Accession Number:

  P08648

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This CD49e antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 796-824 amino acids from the C-terminal region of human CD49e.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  115 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ITGA5

• NCBI Official Name:

  Integrin alpha-5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Boehmler, A.M., J. Immunol. 182 (11), 6789-6798 (2009)

• Background Reference 02:

  Okazaki, T., Am. J. Pathol. 174 (6), 2378-2387 (2009)

• Background Reference 03:

  Schornberg, K.L., Proc. Natl. Acad. Sci. U.S.A. 106 (19), 8003-8008 (2009)

• Other Product Names:

  Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, ITGA5, FNRA

• Tested Applications:

  WB, Flow

• Protein ID:

  23831237

• Physical Properties:

  Liquid