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CD49f Antibody [4F10]

CAT: 0223-99-547Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-99-547Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD49f is the 125 kDa integrin alpha6 chain which associates noncovalently with the integrin beta1 subunit (CD29) and with the integrin beta4 (CD104) chain to form, respectively, the very late antigen-6 (VLA-6) and alpha6beta4 integrin heterodimers. VLA-6 is expressed on thymocytes, T lymphocytes, monocytes, and platelets. CD49f/CD29 expression is upregulated on activated T lymphocytes and memory T cells. VLA-6 serves as the laminin receptor on platelets, monocytes, and T cells. VLA-6-mediated binding to laminin provides a costimulatory signal to T cells for activation and proliferation.
NCBI Gene ID
3655
Swiss Prot
P23229
Accession Number
P23229
Host
Mouse
Reactivity
Human
Immunogen
SW1222 human colorectal cell line
Clonality
Monoclonal
Clone
[4F10]
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Concentration
0.1 mg/mL
Buffer
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store vial at 2-8˚ C
Fragment
IgG2b
Specificity
CD49f
Applications Notes
CD49f Antibody [4F10] for use in flow cytometry, immunohistochemistry, and immunoprecipitation assays.
Symbol
ITGA6
NCBI Official Name
Integrin alpha-6
NCBI Organism
Homo sapiens
Other Product Names
Integrin alpha6 chain, VLA-6 alpha chain, platelet gpIc
Tested Applications
IHC-Fr, Flow
Physical Properties
Liquid

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