ENPP2 Antibody

• Background:

  ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This protein stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. This protein is secreted and further processed to make the biologically active form.

• NCBI Gene ID:

  5168

• Swiss Prot:

  Q13822

• Accession Number:

  Q13822

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ENPP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from the Central region of human ENPP2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  99 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ENPP2

• NCBI Official Name:

  Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kawagoe H., Soma O., Goji J., Nishimura N., Narita M., Genomics 30:380-384 (1995)

• Background Reference 02:

  Nam S.W., Clair T., Kim Y.S., McMarlin A., Cancer Res. 61:6938-6944 (2001)

• Background Reference 03:

  The MGC Project Team Genome Res. 14:2121-2127 (2004)

• Other Product Names:

  Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, E-NPP 2, Autotaxin, Extracellular lysophospholipase D, LysoPLD, ENPP2, ATX, PDNP2

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  290457674

• Physical Properties:

  Liquid