INPP5D Antibody

• Background:

  INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and it is a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5) -trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival.

• NCBI Gene ID:

  3635

• Swiss Prot:

  Q92835

• Accession Number:

  Q92835

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This INPP5D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 770-796 amino acids from the Central region of human INPP5D.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  133 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  INPP5D

• NCBI Official Name:

  Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gilby, D.C., Leukemia 21 (11), 2390-2393 (2007)

• Background Reference 02:

  Gloire, G., Biochem. Soc. Trans. 35 (PT 2), 277-280 (2007)

• Background Reference 03:

  Vaillancourt, M., Cell. Signal. 18 (11), 2022-2032 (2006)

• Other Product Names:

  Phosphatidylinositol 3,5-trisphosphate 5-phosphatase 1, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1, p150Ship, hp51CN, INPP5D, SHIP, SHIP1

• Tested Applications:

  WB

• Protein ID:

  158564077

• Physical Properties:

  Liquid