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INPP5B Antibody

CAT: 0223-55-215Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-215Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases) . INPP5B encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq].
NCBI Gene ID
3633
Swiss Prot
P32019
Accession Number
P32019
Host
Rabbit
Reactivity
Human
Immunogen
This INPP5B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 950-979 amino acids from the C-terminal region of human INPP5B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
113 kDa
Fragment
Rabbit Ig
Symbol
INPP5B
NCBI Official Name
Type II inositol 1,4,5-trisphosphate 5-phosphatase
NCBI Organism
Homo sapiens
Background Reference 01
Coon, B.G., et al. Hum. Mol. Genet. 18 (23) :4478-4491 (2009)
Background Reference 02
Mao, Y., et al. EMBO J. 28 (13) :1831-1842 (2009)
Background Reference 03
Williams, C., et al. J. Cell. Sci. 120 (PT 22), 3941-3951 (2007) :
Background Reference 04
Speed, C.J., et al. Eur. J. Biochem. 234 (1) :216-224 (1995)
Other Product Names
Type II inositol 1,5-trisphosphate 5-phosphatase, 75 kDa inositol polyphosphate-5-phosphatase, Phosphoinositide 5-phosphatase, 5PTase, INPP5B, OCRL2
Tested Applications
WB, IHC-P, Flow
Protein ID
281185510
Physical Properties
Liquid

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