IRF8 Antibody

• Background:

  Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.

• NCBI Gene ID:

  3394

• Swiss Prot:

  Q02556

• Accession Number:

  Q02556

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This IRF8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-269 amino acids from the Central region of human IRF8.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  IRF8

• NCBI Official Name:

  Interferon regulatory factor 8

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  McGough, J.M., Mol. Cancer Res. (12), 1841-1851 (2008)

• Background Reference 02:

  Tshuikina, M., Exp. Hematol. 36 (12), 1673-1681 (2008)

• Background Reference 03:

  Martinez, A., Am. J. Surg. Pathol. 32 (8), 1190-1200 (2008)

• Other Product Names:

  Interferon regulatory factor 8, IRF-8, Interferon consensus sequence-binding protein, H-ICSBP, ICSBP, IRF8, ICSBP1

• Tested Applications:

  WB, Flow

• Protein ID:

  6016308

• Physical Properties:

  Liquid