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ATXN1 Antibody

CAT: 0223-61-519Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-519Size:400 µL
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Background
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known.
NCBI Gene ID
6310
Swiss Prot
P54253
Accession Number
P54253
Host
Rabbit
Reactivity
Human
Immunogen
This ATXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 754-781 amino acids from human ATXN1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
87 kDa
Fragment
Rabbit Ig
Symbol
ATXN1
NCBI Official Name
Ataxin-1
NCBI Organism
Homo sapiens
Background Reference 01
Hong, S., Biochem. Biophys. Res. Commun. 371 (2), 256-260 (2008)
Background Reference 02
Lim, J., Nature 452 (7188), 713-718 (2008)
Background Reference 03
Krol, H.A., PLoS ONE (1), E1503 (2008)
Other Product Names
Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1
Tested Applications
WB, IF
Protein ID
206729854
Physical Properties
Liquid

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