HNF4A Antibody

• Background:

  HNF4A is a nuclear transcription factor which binds DNA as a homodimer. This protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This protein may play a role in development of the liver, kidney, and intestines. Mutations in HNF4A gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I.

• NCBI Gene ID:

  3172

• Swiss Prot:

  P41235

• Accession Number:

  P41235

• Host:

  Rabbit

• Reactivity:

  Human, Rat

• Immunogen:

  This HNF4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-312 amino acids from the Central region of human HNF4A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  53 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  HNF4A

• NCBI Official Name:

  Hepatocyte nuclear factor 4-alpha

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kritis A.A., Argyrokastritis A.Gene 173:275-280 (1996)

• Background Reference 02:

  Yamagata K., Furuta H., Oda N.Nature 384:458-460 (1996)

• Background Reference 03:

  Furuta H., Iwasaki N., Oda N.Diabetes 46:1652-1657 (1997)

• Background Reference 04:

  Moeller A.M., Urhammer S.A.Diabetologia 40:980-983 (1997)

• Other Product Names:

  Hepatocyte nuclear factor 4-alpha, HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4, HNF4A, HNF4, NR2A1, TCF14

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  148886624

• Physical Properties:

  Liquid