MCAM Antibody

• Background :

  MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. It could be an adhesion molecule active in neural crest cells during embryonic development. It acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.

• NCBI Gene ID :

  4162

• Swiss Prot :

  P43121

• Accession Number :

  P43121

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This MCAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-189 amino acids from the Central region of human MCAM.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Immunology, Signal Transduction

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  72 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  MCAM

• NCBI Official Name :

  Cell surface glycoprotein MUC18

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Fritzsche, F.R., Pathology 40 (5), 457-464 (2008)

• Background Reference 02 :

  Malyszko, J., Clin. Appl. Thromb. Hemost. 14 (3), 338-345 (2008)

• Background Reference 03 :

  Guezguez, B., J. Immunol. 179 (10), 6673-6685 (2007)

• Other Product Names :

  Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12, Melanoma cell adhesion molecule, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, S-endo 1 endothelial-associated antigen, CD146, MCAM, MUC18

• Tested Applications :

  WB, IHC-P, Flow

• Protein ID :

  85681878

• Physical Properties :

  Liquid