MGAT2 Antibody

• Background:

  MGAT2 (UDP-N-acetylglucosamine:alpha-6-D-mannoside-beta-1, 2-N-acetylglucosaminyltransferase II) is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in MGAT2 may lead to carbohydrate-deficient glycoprotein syndrome, type II.

• NCBI Gene ID:

  4247

• Swiss Prot:

  Q10469

• Accession Number:

  Q10469

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MGAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 409-439 amino acids from the C-terminal region of human MGAT2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  52 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MGAT2

• NCBI Official Name:

  Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yen, C.L., et al., J. Biol. Chem. 278 (20) :18532-18537 (2003) . Chen, S.H., et al., Glycoconj. J. 15 (3) :301-308 (1998) . Tan, J., et al., Am. J. Hum. Genet. 59 (4) :810-817 (1996) . Tan, J., et al., Eur. J. Biochem. 231 (2) :317-328 (1995) . D'Agostaro, G.A., et al., J. Biol. Chem. 270 (25) :15211-15221 (1995) .

• Other Product Names:

  Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, Beta-1,2-N-acetylglucosaminyltransferase II, GlcNAc-T II, GNT-II, Mannoside acetylglucosaminyltransferase 2, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II, MGAT2

• Tested Applications:

  WB, Flow

• Protein ID:

  1708004

• Physical Properties:

  Liquid