APOBEC3C Antibody

• Background:

  DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

• NCBI Gene ID:

  27350

• Swiss Prot:

  Q9NRW3

• Accession Number:

  Q9NRW3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This APOBEC3C antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 143-177 amino acids from human APOBEC3C.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  23 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:2000

• Symbol:

  APOBEC3C

• NCBI Official Name:

  DNA dC->dU-editing enzyme APOBEC-3C

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gu J., et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.

• Background Reference 02:

  Collins J.E., et al.Genome Biol. 5:R84.1-R84.11 (2004) .

• Background Reference 03:

  Ota T., et al.Nat. Genet. 36:40-45 (2004) .

• Background Reference 04:

  Dunham I., et al.Nature 402:489-495 (1999) .

• Other Product Names:

  DNA dC->dU-editing enzyme APOBEC-3C, A3C, 3.5.4.-, APOBEC1-like, Phorbolin I, APOBEC3C, APOBEC1L, PBI

• Tested Applications:

  WB

• Protein ID:

  48474983

• Physical Properties:

  Liquid