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APOBEC3C Antibody

CAT: 0223-61-357Size: 200 µLDry Ice: NoHazardous: No
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CAT#:0223-61-357Size:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
NCBI Gene ID
27350
Swiss Prot
Q9NRW3
Accession Number
Q9NRW3
Host
Rabbit
Reactivity
Human
Immunogen
This APOBEC3C antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 143-177 amino acids from human APOBEC3C.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
23 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
APOBEC3C
NCBI Official Name
DNA dC->dU-editing enzyme APOBEC-3C
NCBI Organism
Homo sapiens
Background Reference 01
Gu J., et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Background Reference 02
Collins J.E., et al.Genome Biol. 5:R84.1-R84.11 (2004) .
Background Reference 03
Ota T., et al.Nat. Genet. 36:40-45 (2004) .
Background Reference 04
Dunham I., et al.Nature 402:489-495 (1999) .
Other Product Names
DNA dC->dU-editing enzyme APOBEC-3C, A3C, 3.5.4.-, APOBEC1-like, Phorbolin I, APOBEC3C, APOBEC1L, PBI
Tested Applications
WB
Protein ID
48474983
Physical Properties
Liquid

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