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Profilin-1 Antibody

CAT: 0223-61-323Size: 200 µLDry Ice: NoHazardous: No
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CAT#:0223-61-323Size:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
NCBI Gene ID
5216
Swiss Prot
P07737
Accession Number
P07737
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This Profilin-1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 108-140 amino acids from the human region of human Profilin-1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
15 kDa
Fragment
Rabbit Ig
Symbol
PFN1
NCBI Official Name
Profilin-1
NCBI Organism
Homo sapiens
Background Reference 01
Kwiatkowski D.J., et al.J. Biol. Chem. 263:5910-5915 (1988) .
Background Reference 02
Li J., et al.Mol. Cell. Proteomics 9:2517-2528 (2010) .
Background Reference 03
Kalnine N., et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Background Reference 04
Ota T., et al.Nat. Genet. 36:40-45 (2004) .
Other Product Names
Profilin-1, Epididymis tissue protein Li 184a, Profilin I, PFN1
Tested Applications
WB, Flow
Protein ID
130979
Physical Properties
Liquid

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