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SLC5A8 Antibody

CAT: 0223-61-237Size: 200 µLDry Ice: NoHazardous: No
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CAT#:0223-61-237Size:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Acts as an electrogenic sodium (Na (+) ) and chloride (Cl-) -dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na (+) :substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na (+) gradient and hence contribute to the maintenance of the energy status and function of neurons.
NCBI Gene ID
160728
Swiss Prot
Q8N695
Accession Number
Q8N695
Host
Rabbit
Reactivity
Human
Immunogen
This SLC5A8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 579-609 amino acids from the human SLC5A8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
67 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SLC5A8
NCBI Official Name
Sodium-coupled monocarboxylate transporter 1
NCBI Organism
Homo sapiens
Background Reference 01
Rodriguez A.-M., et al.J. Clin. Endocrinol. Metab. 87:3500-3503 (2002) .
Background Reference 02
Li H., et al.Proc. Natl. Acad. Sci. U.S.A. 100:8412-8417 (2003) .
Background Reference 03
Miyauchi S., et al.J. Biol. Chem. 279:13293-13296 (2004) .
Background Reference 04
Coady M.J., et al.J. Physiol. (Lond.) 557:719-731 (2004) .
Other Product Names
Sodium-coupled monocarboxylate transporter 1, Apical iodide transporter, Electrogenic sodium monocarboxylate cotransporter, Sodium iodide-related cotransporter, Solute carrier family 5 member 8, SLC5A8 {ECO:0000312|EMBL:AAP46193.1}
Tested Applications
WB
Protein ID
296452898
Physical Properties
Liquid

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