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NMNAT1 Antibody

CAT: 0223-61-159Size: 200 µLDry Ice: NoHazardous: No
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CAT#:0223-61-159Size:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Catalyzes the formation of NAD (+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD (+) . For the pyrophosphorolytic activity, prefers NAD (+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP (+), NADPH and NAADP (+) . Protects against axonal degeneration following mechanical or toxic insults.
NCBI Gene ID
64802
Swiss Prot
Q9HAN9
Accession Number
Q9HAN9
Host
Rabbit
Reactivity
Human
Immunogen
This NMNAT1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 200-232 amino acids from human NMNAT1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
32 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
NMNAT1
NCBI Official Name
Nicotinamide mononucleotide adenylyltransferase 1
NCBI Organism
Homo sapiens
Background Reference 01
Schweiger M., et al.FEBS Lett. 492:95-100 (2001) .
Background Reference 02
Emanuelli M., et al.J. Biol. Chem. 276:406-412 (2001) .
Background Reference 03
Fernando F.S., et al.Gene 284:23-29 (2002) .
Background Reference 04
Ota T., et al.Nat. Genet. 36:40-45 (2004) .
Other Product Names
Nicotinamide mononucleotide adenylyltransferase 1, NMN adenylyltransferase 1, 2.7.7.1, Nicotinate-nucleotide adenylyltransferase 1, NaMN adenylyltransferase 1, 2.7.7.18, NMNAT1, NMNAT
Tested Applications
WB
Protein ID
30580491
Physical Properties
Liquid

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