Products for Research Use Only
RegisterLogin

KCTD11 Antibody

CAT: 0223-61-142Size: 200 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-61-142Size:200 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB) . Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
NCBI Gene ID
147040
Swiss Prot
Q693B1
Accession Number
Q693B1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This KCTD11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-53 amino acids from human KCTD11.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
26 kDa
Fragment
Rabbit Ig
Symbol
KCTD11
NCBI Official Name
BTB/POZ domain-containing protein KCTD11
NCBI Organism
Homo sapiens
Background Reference 01
Di Marcotullio L., et al.Proc. Natl. Acad. Sci. U.S.A. 101:10833-10838 (2004) .
Background Reference 02
Correale S., et al.Biochimie 93:715-724 (2011) .
Background Reference 03
Ota T., et al.Nat. Genet. 36:40-45 (2004) .
Background Reference 04
Mural R.J., et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Other Product Names
BTB/POZ domain-containing protein KCTD11, KCTD11, C17orf36, REN
Tested Applications
WB, IHC-P
Protein ID
74708977
Physical Properties
Liquid

Related Products

CatalogName
42-417PKCTD11 Peptide
57-028KCTD10 Antibody
5085-002mgKCTD15 Antibody
60-243KCTD17 Antibody
14-202KCTD10 Antibody
5085-01KCTD15 Antibody
63-866KCTD12 Antibody
25-377KCTD19 Antibody
61-916KCTD21 Antibody
5085-01mgKCTD15 Antibody

Alternative Products

CatalogName
70R-1491KCTD11 antibody
MBS8325312-01Anti-KCTD11 Antibody
bs-9637RKCTD11 Polyclonal Antibody
abx376376-01BTB/POZ Domain-Containing Protein KCTD11 (KCTD11) Antibody
GTR18993528KCTD11 Antibody Blocking Peptide
GTR18318219-01KCTD11 Rabbit Polyclonal Antibody
MBS422601-01Goat anti-KCTD11 Antibody
NBP1-80211Rabbit Polyclonal KCTD11 Antibody
NBP1-72049Goat Polyclonal KCTD11 Antibody
MBS9216990-01KCTD11 Antibody (N-Term)

Popular Products