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USP7 Antibody

CAT: 0223-61-101Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-101Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
NCBI Gene ID
7874
Swiss Prot
Q93009
Accession Number
Q93009
Host
Rabbit
Reactivity
Human
Immunogen
This USP7 (HAUSP) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1060-1090 amino acids from the C-terminal region of human USP7 (HAUSP) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
128 kDa
Fragment
Rabbit Ig
Symbol
USP7
NCBI Official Name
Ubiquitin carboxyl-terminal hydrolase 7
NCBI Organism
Homo sapiens
Background Reference 01
Puente, X.S., et al., Nat. Rev. Genet. 4 (7) :544-558 (2003) .
Background Reference 02
Li, M., et al., Nature 416 (6881) :648-653 (2002) .
Background Reference 03
D'Andrea, A., et al., Crit. Rev. Biochem. Mol. Biol. 33 (5) :337-352 (1998) .
Background Reference 04
Everett, R.D., et al., EMBO J. 16 (3) :566-577 (1997) .
Other Product Names
Ubiquitin carboxyl-terminal hydrolase 7, Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7, USP7, HAUSP
Tested Applications
WB, IHC-P
Protein ID
212276477
Physical Properties
Liquid

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