USP1 Antibody

• Background:

  This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.

• NCBI Gene ID:

  7398

• Swiss Prot:

  O94782

• Accession Number:

  O94782

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This USP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 662-690 amino acids from the C-terminal region of human USP1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  88 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  USP1

• NCBI Official Name:

  Ubiquitin carboxyl-terminal hydrolase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Barroso, E., et al. Breast Cancer Res. Treat. 118 (3) :655-660 (2009)

• Background Reference 02:

  McWilliams, R.R., et al. Cancer Epidemiol. Biomarkers Prev. 18 (9) :2549-2552 (2009)

• Background Reference 03:

  Cohn, M.A., et al. J. Biol. Chem. 284 (8) :5343-5351 (2009)

• Background Reference 04:

  Cohn, M.A., et al. Mol. Cell 28 (5) :786-797 (2007)

• Other Product Names:

  Ubiquitin carboxyl-terminal hydrolase 1, Deubiquitinating enzyme 1, hUBP, Ubiquitin thioesterase 1, Ubiquitin-specific-processing protease 1, USP1

• Tested Applications:

  WB

• Physical Properties:

  Liquid