HIP2 Antibody

• Background:

  HIP2 belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.

• NCBI Gene ID:

  3093

• Swiss Prot:

  P61086

• Accession Number:

  P61086

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This HIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-139 amino acids from the Central region of human HIP2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Neuroscience

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  22 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  UBE2K

• NCBI Official Name:

  Ubiquitin-conjugating enzyme E2 K

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Furukawa, Y., et al., Electrophoresis 21 (2) :338-346 (2000) .

• Background Reference 02:

  Kikuchi, J., et al., Arterioscler. Thromb. Vasc. Biol. 20 (1) :128-134 (2000) .

• Background Reference 03:

  Petersen, A., et al., Exp. Neurol. 157 (1) :1-18 (1999) .

• Background Reference 04:

  Kalchman, M.A., et al., J. Biol. Chem. 271 (32) :19385-19394 (1996) .

• Other Product Names:

  Ubiquitin-conjugating enzyme E2 K, Huntingtin-interacting protein 2, HIP-2, Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2-25 kDa, Ubiquitin-conjugating enzyme E2 (25K), Ubiquitin-conjugating enzyme E2-25K, Ubiquitin-protein ligase, UBE2K, HIP2, LIG

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  46577658

• Physical Properties:

  Liquid