Products for Research Use Only
RegisterLogin

NPC1L1 Antibody

CAT: 0223-60-959Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-60-959Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E) . The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
29881
Swiss Prot
Q9UHC9
Accession Number
Q9UHC9
Host
Rabbit
Reactivity
Human
Immunogen
This NPC1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-323 amino acids from the N-terminal region of human NPC1L1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
149 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NPC1L1
NCBI Official Name
Niemann-Pick C1-like protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Hu, M., et al. Pharmacogenet. Genomics 20 (10) :634-637 (2010)
Background Reference 02
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 03
Teslovich, T.M., et al. Nature 466 (7307) :707-713 (2010)
Background Reference 04
Pramfalk, C., et al. J. Lipid Res. 51 (6) :1354-1362 (2010)
Other Product Names
Niemann-Pick C1-like protein 1, NPC1L1
Tested Applications
WB
Protein ID
425906049
Physical Properties
Liquid

Related Products

CatalogName
42-346PNpc1l1 Peptide
42-347PNpc1l1 Peptide
5185-01mgNPC1 Antibody
43-348NPC1 Antibody
5185-002mgNPC1 Antibody
42-605Npc1 Antibody
5185-01NPC1 Antibody
5185PNPC1 Peptide
42-605PNpc1 Peptide
43-348PNPC1 Peptide

Alternative Products

CatalogName
A76404-100ULNPC1L1 Antibody
RAC07549-01Npc1L1 Recombinant Antibody
C45306NPC1L1 Conjugated Antibody
STJ112089Anti-NPC1L1 antibody
GTR17699168Npc1l1 (mouse) Antibody
E910049NPC1L1 Polyclonal Antibody
526076-01NPC1L1

Popular Products