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APOBEC3A Antibody

CAT: 0223-60-931Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-931Size:400 µL
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Background
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. One allele of this gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3A, and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B.
NCBI Gene ID
100913187200315
Swiss Prot
P31941
Accession Number
P31941
Host
Rabbit
Reactivity
Human
Immunogen
This APOBEC3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human APOBEC3A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
23 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
APOBEC3A
NCBI Official Name
DNA dC->dU-editing enzyme APOBEC-3A
NCBI Organism
Homo sapiens
Background Reference 01
Thielen, B.K., et al. J. Biol. Chem. 285 (36) :27753-27766 (2010)
Background Reference 02
Berger, A., et al. J. Biol. Chem. 285 (16) :12248-12254 (2010)
Background Reference 03
Stenglein, M.D., et al. Nat. Struct. Mol. Biol. 17 (2) :222-229 (2010)
Background Reference 04
Abe, H., et al. Hepatol. Res. 39 (12) :1159-1168 (2009)
Other Product Names
DNA dC->dU-editing enzyme APOBEC-3A, A3A, 354-, Phorbolin-1, APOBEC3A
Tested Applications
WB
Protein ID
12644206
Physical Properties
Liquid

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