APOBEC3A Antibody

• Background:

  This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. One allele of this gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3A, and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B.

• NCBI Gene ID:

  100913187200315

• Swiss Prot:

  P31941

• Accession Number:

  P31941

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This APOBEC3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human APOBEC3A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  23 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  APOBEC3A

• NCBI Official Name:

  DNA dC->dU-editing enzyme APOBEC-3A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Thielen, B.K., et al. J. Biol. Chem. 285 (36) :27753-27766 (2010)

• Background Reference 02:

  Berger, A., et al. J. Biol. Chem. 285 (16) :12248-12254 (2010)

• Background Reference 03:

  Stenglein, M.D., et al. Nat. Struct. Mol. Biol. 17 (2) :222-229 (2010)

• Background Reference 04:

  Abe, H., et al. Hepatol. Res. 39 (12) :1159-1168 (2009)

• Other Product Names:

  DNA dC->dU-editing enzyme APOBEC-3A, A3A, 354-, Phorbolin-1, APOBEC3A

• Tested Applications:

  WB

• Protein ID:

  12644206

• Physical Properties:

  Liquid