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IRF3 Antibody

CAT: 0223-3397-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3397-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IRF3 Antibody: Interferons (IFN) s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF3 is present in an inactive form in the cytoplasm of most cells. Following viral infection, IRF3 can be activated by Iκ B kinase-ε and TANK-binding kinase 1 (TBK1), whereupon IRF3 translocates to the nucleus. IRF3 can also be activated by stimulation of toll-like receptor 3 (TLR3) by dsRNA. IRF3 exists as at least two distinct isoforms.
NCBI Gene ID
3661
Swiss Prot
Q14653
Accession Number
NP_001562
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Chemokines & Cytokines, Homeostasis, Inflammasomes
Purification
IRF3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1225 - Ramos Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (86%), Pig: (79%)
Buffer
IRF3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IRF3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43, 47, 50 kDa
Fragment
IgG
Specificity
At least three isoforms of IRF3 are known to exist.
Symbol
IRF3
Positive Control 2
Cat. No. 1405 - Mouse Kidney Tissue Lysate
NCBI Official Name
Interferon regulatory factor 3
NCBI Organism
Homo sapiens
Background Reference 01
Malmgaard L. Induction and regulation of IFNs during viral infections. J. Interferon & Cyto. Res. 2004; 24:439-54
Background Reference 02
Au WC, Moore PA, Lowther W, et al. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. Proc. Natl. Acad. Sci. USA 1995; 92:11657-61.
Background Reference 03
Fitzgerald KA, McWhirter SM, Faia KL, et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 2003; 4:491-6.
Background Reference 04
Sharma S, Tenoever BR, Grandvaux N, et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 2003; 300:1148-51.
Other Product Names
IRF3 Antibody: Interferon regulatory factor 3, IRF-3
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4504725
Physical Properties
Liquid

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