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GPR77 Antibody

CAT: 0223-60-836Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-836Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate complement activation, anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM 113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 [PubMed 16204243]) .
NCBI Gene ID
27202
Swiss Prot
Q9P296
Accession Number
Q9P296
Host
Rabbit
Reactivity
Human
Immunogen
This GPR77 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 297-325 amino acids from the C-terminal region of human GPR77.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
36 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
C5AR2
NCBI Official Name
C5a anaphylatoxin chemotactic receptor 2
NCBI Organism
Homo sapiens
Background Reference 01
Bamberg, C.E., et al. J. Biol. Chem. 285 (10) :7633-7644 (2010)
Background Reference 02
Cui, W., et al. Mol. Immunol. 46 (16) :3207-3217 (2009)
Background Reference 03
Cui, W., et al. Mol. Immunol. 46 (15) :3086-3098 (2009)
Background Reference 04
Scola, A.M., et al. Mol. Immunol. 46 (6) :1149-1162 (2009)
Other Product Names
C5a anaphylatoxin chemotactic receptor 2, Complement component 5a receptor 2, G-protein coupled receptor 77, C5AR2, C5L2, GPR77
Tested Applications
WB
Protein ID
20137533
Physical Properties
Liquid

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