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EGFR Antibody

CAT: 0223-60-735Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-735Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
NCBI Gene ID
1956
Swiss Prot
P00533
Accession Number
P00533
Host
Rabbit
Reactivity
Human
Immunogen
This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 259-287 amino acids from the N-terminal region of human EGFR.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Chicken
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
134 kDa
Fragment
Rabbit Ig
Symbol
EGFR
NCBI Official Name
Epidermal growth factor receptor
NCBI Organism
Homo sapiens
Background Reference 01
Abdallah, R.T., et al. J. Biol. Chem. 285 (45) :35206-35215 (2010)
Background Reference 02
Lu, C., et al. Mol. Cell. Biol. 30 (22) :5432-5443 (2010)
Background Reference 03
Rosell, R., et al. Ann. N. Y. Acad. Sci. 1210, 45-52 (2010) :
Background Reference 04
Hata, A., et al.Thorac Oncol 5 (10) :1524-1528 (2010)
Other Product Names
Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1
Tested Applications
WB, IHC-P
Protein ID
2811086
Physical Properties
Liquid

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