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NCAPH2 Antibody

CAT: 0223-60-691Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-691Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Structural maintenance of chromosomes (SMC) and non-SMC condensin proteins associate into complexes that have been implicated in the process of chromosome condensation. A crucial prerequisite for accurate segregation of replicated sister chromatids is the condensation of the chromosomes into a manageable form prior to metaphase. The condensin I complex consists of two SMC subunits, SMC2 and SMC4, and three non-SMC subunits, CAP-H, CAP-G, and CAP-D2. An alternative complex, the condensin II complex, contains alternate non-SMC subunits, CAP-G2, CAP-H2, and CAP-D3. CAP-H2 is also known as Non-SMC condensin II complex, subunit H2 (NCAPH2) or kleisin beta isoform 2. The three non-SMC subunits in the condensing complexes form a regulatory subcomplex that is required to activate the SMC ATPases and to promote mitosis-specific chromatin binding of the holocomplex. The precise individual functions of each non-SMC protein in activation remain to be determined.
NCBI Gene ID
29781
Swiss Prot
Q6IBW4
Accession Number
Q6IBW4
Host
Rabbit
Reactivity
Human
Immunogen
This NCAPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-227 amino acids from the N-terminal region of human NCAPH2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
68 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NCAPH2
NCBI Official Name
Condensin-2 complex subunit H2
NCBI Organism
Homo sapiens
Background Reference 01
Ono, T., et al. Cell 115 (1), 109-121 (2003) .
Background Reference 02
Schleiffer, A., et al. Mol. Cell 11 (3), 571-575 (2003) .
Background Reference 03
Loftus, B.J., et al., Genomics 60 (3) :295-308 (1999) .
Other Product Names
Condensin-2 complex subunit H2, Chromosome-associated protein H2, hCAP-H2, Kleisin-beta, Non-SMC condensin II complex subunit H2, NCAPH2, CAPH2
Tested Applications
WB
Protein ID
74709496
Physical Properties
Liquid

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