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HERC3 Antibody

CAT: 0223-60-595Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-595Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HERC3 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710) -like domain (RLD) . The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]) .
NCBI Gene ID
8916
Swiss Prot
Q15034
Accession Number
Q15034
Host
Rabbit
Reactivity
Human
Immunogen
This HERC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-77 amino acids from the N-terminal region of human HERC3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
117 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
HERC3
NCBI Official Name
Probable E3 ubiquitin-protein ligase HERC3
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Hochrainer, K., et al. Genomics 85 (2) :153-164 (2005)
Background Reference 03
Cruz, C., et al. FEBS Lett. 488 (1-2), 74-80 (2001) :
Background Reference 04
Cruz, C., et al. Cytogenet. Cell Genet. 87 (3-4), 263-264 (1999) :
Other Product Names
Probable E3 ubiquitin-protein ligase HERC3, 632-, HECT domain and RCC1-like domain-containing protein 3, HERC3, KIAA0032
Tested Applications
WB
Protein ID
2495699
Physical Properties
Liquid

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