NMD3 Antibody

• Background:

  It has been suggested that NMD3 is a cytoplasmic factor required for a late cytoplasmic assembly step of the 60S subunit but is not a ribosomal protein. A mutation in NMD3 was found to be lethal in the absence of XRN1, which encodes the major cytoplasmic exoribonuclease responsible for mRNA turnover. The NMD3 protein sequence does not contain readily recognizable motifs of known function. However, NMD3 orthologues display an amino-terminal domain containing four repeats of Cx2C, reminiscent of zinc-binding proteins, implicated in nucleic acid binding or protein oligomerization.

• NCBI Gene ID:

  51068

• Swiss Prot:

  Q96D46

• Accession Number:

  Q96D46

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This NMD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-440 amino acids from the C-terminal region of human NMD3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  58 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  NMD3

• NCBI Official Name:

  60S ribosomal export protein NMD3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Trotta, C.R., et al., EMBO J. 22 (11) :2841-2851 (2003) .

• Background Reference 02:

  Ho, J.H. et al., Mol. Cell. Bio., 19 (3) :2389-2399 (1999) .

• Other Product Names:

  60S ribosomal export protein NMD3, hNMD3, NMD3

• Tested Applications:

  WB

• Protein ID:

  74731412

• Physical Properties:

  Liquid