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NDUFV1 Antibody

CAT: 0223-60-532Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-532Size:400 µL
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Background
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V) . This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN) - and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
NCBI Gene ID
4723
Swiss Prot
P49821
Accession Number
P49821
Host
Rabbit
Reactivity
Human
Immunogen
This NDUFV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-50 amino acids from the N-terminal region of human NDUFV1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Monkey, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
51 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NDUFV1
NCBI Official Name
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Wang, W., et al. Nucleic Acids Res. (2010) In press :
Background Reference 02
Moran, M., et al. Biochim. Biophys. Acta 1802 (5) :443-453 (2010)
Background Reference 03
Saito, A., et al. J. Hum. Genet. 54 (6) :317-323 (2009)
Background Reference 04
Starr, J.M., et al. Mech. Ageing Dev. 129 (12) :745-751 (2008)
Other Product Names
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, Complex I-51kD, CI-51kD, NADH dehydrogenase flavoprotein 1, NADH-ubiquinone oxidoreductase 51 kDa subunit, NDUFV1, UQOR1
Tested Applications
WB
Protein ID
20455501
Physical Properties
Liquid

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