TNPO1 Antibody

• Background:

  TNPO1 comprises the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins.

• NCBI Gene ID:

  3842

• Swiss Prot:

  Q92973

• Accession Number:

  Q92973

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TNPO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-74 amino acids from the N-terminal region of human TNPO1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  102 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TNPO1

• NCBI Official Name:

  Transportin-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Fineberg, K., et al., Biochemistry 42 (9) :2625-2633 (2003) .

• Background Reference 02:

  Nelson, L.M., et al., Virology 306 (1) :162-169 (2003) .

• Background Reference 03:

  Le Roux, L.G., et al., J. Virol. 77 (4) :2330-2337 (2003) .

• Background Reference 04:

  Limon, A., et al., J. Virol. 76 (21) :10598-10607 (2002) .

• Other Product Names:

  Transportin-1, Importin beta-2, Karyopherin beta-2, M9 region interaction protein, MIP, TNPO1, KPNB2, MIP1, TRN

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  259016171

• Physical Properties:

  Liquid