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APC Antibody

CAT: 0223-60-427Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-427Size:400 µL
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Background
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
NCBI Gene ID
324
Swiss Prot
P25054
Accession Number
P25054
Host
Rabbit
Reactivity
Mouse
Immunogen
This APC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1148-1176 amino acids from the Central region of human APC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
312 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
APC
NCBI Official Name
Adenomatous polyposis coli protein
NCBI Organism
Homo sapiens
Background Reference 01
Chung, K.H., et al.Neurosurg Pediatr 6 (4) :372-376 (2010)
Background Reference 02
Rai, K., et al. Cell 142 (6) :930-942 (2010)
Background Reference 03
Poulogiannis, G., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (34) :15145-15150 (2010)
Background Reference 04
Jaulin, F., et al. J. Cell Biol. 190 (3) :443-460 (2010)
Other Product Names
Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 25, APC, DP25
Tested Applications
WB
Protein ID
97535708
Physical Properties
Liquid

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