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SPINT2 Antibody

CAT: 0223-60-423Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-423Size:400 µL
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Background
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
NCBI Gene ID
10653
Swiss Prot
O43291
Accession Number
O43291
Host
Rabbit
Reactivity
Human
Immunogen
This SPINT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-251 amino acids from the C-terminal region of human SPINT2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Cell Cycle, Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
28 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SPINT2
NCBI Official Name
Kunitz-type protease inhibitor 2
NCBI Organism
Homo sapiens
Background Reference 01
Dong, W., et al. Int. J. Cancer 127 (7) :1526-1534 (2010)
Background Reference 02
Bergum, C., et al. Prostate 70 (13) :1422-1428 (2010)
Background Reference 03
Sivagnanam, M., et al. Clin. Dysmorphol. 19 (1), 48 (2010) :
Background Reference 04
Yamauchi, M., et al. Biol. Chem. 383 (12) :1953-1957 (2002)
Other Product Names
Kunitz-type protease inhibitor 2, Hepatocyte growth factor activator inhibitor type 2, HAI-2, Placental bikunin, SPINT2, HAI2, KOP
Tested Applications
WB
Physical Properties
Liquid

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