SPINT2 Antibody

• Background:

  This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

• NCBI Gene ID:

  10653

• Swiss Prot:

  O43291

• Accession Number:

  O43291

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SPINT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-251 amino acids from the C-terminal region of human SPINT2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Cell Cycle, Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  28 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SPINT2

• NCBI Official Name:

  Kunitz-type protease inhibitor 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Dong, W., et al. Int. J. Cancer 127 (7) :1526-1534 (2010)

• Background Reference 02:

  Bergum, C., et al. Prostate 70 (13) :1422-1428 (2010)

• Background Reference 03:

  Sivagnanam, M., et al. Clin. Dysmorphol. 19 (1), 48 (2010) :

• Background Reference 04:

  Yamauchi, M., et al. Biol. Chem. 383 (12) :1953-1957 (2002)

• Other Product Names:

  Kunitz-type protease inhibitor 2, Hepatocyte growth factor activator inhibitor type 2, HAI-2, Placental bikunin, SPINT2, HAI2, KOP

• Tested Applications:

  WB

• Physical Properties:

  Liquid