Mouse Cbx5 Antibody

• Background:

  Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) . Can interact with lamin-B receptor (LBR) . This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity) .

• NCBI Gene ID:

  12419

• Swiss Prot:

  Q61686

• Accession Number:

  Q61686

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This Mouse Cbx5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-186 amino acids from the C-terminal region of mouse Cbx5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Human

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  22 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  Cbx5

• NCBI Official Name:

  Chromobox protein homolog 5

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Sun, Y., et al. Biophys. J. 99 (4) :1274-1283 (2010)

• Background Reference 02:

  Muller, K.P., et al. Biophys. J. 97 (11) :2876-2885 (2009)

• Background Reference 03:

  Dong, K.B., et al. EMBO J. 27 (20) :2691-2701 (2008)

• Background Reference 04:

  Villeneuve, L.M., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (26) :9047-9052 (2008)

• Other Product Names:

  Chromobox protein homolog 5, Heterochromatin protein 1 homolog alpha, HP1 alpha, Cbx5, Hp1a

• Tested Applications:

  WB

• Physical Properties:

  Liquid