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Mouse Cbx5 Antibody

CAT: 0223-60-399Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-399Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) . Can interact with lamin-B receptor (LBR) . This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity) .
NCBI Gene ID
12419
Swiss Prot
Q61686
Accession Number
Q61686
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Cbx5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-186 amino acids from the C-terminal region of mouse Cbx5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Human
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
22 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Cbx5
NCBI Official Name
Chromobox protein homolog 5
NCBI Organism
Mus musculus
Background Reference 01
Sun, Y., et al. Biophys. J. 99 (4) :1274-1283 (2010)
Background Reference 02
Muller, K.P., et al. Biophys. J. 97 (11) :2876-2885 (2009)
Background Reference 03
Dong, K.B., et al. EMBO J. 27 (20) :2691-2701 (2008)
Background Reference 04
Villeneuve, L.M., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (26) :9047-9052 (2008)
Other Product Names
Chromobox protein homolog 5, Heterochromatin protein 1 homolog alpha, HP1 alpha, Cbx5, Hp1a
Tested Applications
WB
Physical Properties
Liquid

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