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Mouse Cdkn2a Antibody

CAT: 0223-60-398Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-398Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.
NCBI Gene ID
12578
Swiss Prot
Q64364
Accession Number
Q64364
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Cdkn2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-65 amino acids from the Central region of mouse Cdkn2a.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
19 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Cdkn2a
NCBI Official Name
Cyclin-dependent kinase inhibitor 2A, isoform 3
NCBI Organism
Mus musculus
Background Reference 01
Nogueira, C., et al. Oncogene 29 (47) :6222-6232 (2010)
Background Reference 02
Fernandez-Diaz, L.C., et al. Development 137 (20) :3393-3403 (2010)
Background Reference 03
Bennecke, M., et al. Cancer Cell 18 (2) :135-146 (2010)
Background Reference 04
Negishi, M., et al. PLoS ONE (8), E12373 (2010) :
Other Product Names
Cyclin-dependent kinase inhibitor 2A, isoform 3, p19ARF, Cdkn2a {ECO:0000312|EMBL:AAB357701, ECO:0000312|MGI:MGI:104738}
Tested Applications
WB
Physical Properties
Liquid

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