DMRT1 Antibody

• Background:

  This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain) . The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.

• NCBI Gene ID:

  1761

• Swiss Prot:

  Q9Y5R6

• Accession Number:

  Q9Y5R6

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DMRT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-322 amino acids from the C-terminal region of human DMRT1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  39 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DMRT1

• NCBI Official Name:

  Doublesex- and mab-3-related transcription factor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kang, J.U., et al. Int. J. Oncol. 37 (2) :327-335 (2010)

• Background Reference 02:

  Turnbull, C., et al. Nat. Genet. 42 (7) :604-607 (2010)

• Background Reference 03:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 04:

  Krentz, A.D., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (52) :22323-22328 (2009)

• Other Product Names:

  Doublesex- and mab-3-related transcription factor 1, DM domain expressed in testis protein 1, DMRT1, DMT1

• Tested Applications:

  WB

• Protein ID:

  83305820

• Physical Properties:

  Liquid