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DMRT1 Antibody

CAT: 0223-60-338Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-338Size:400 µL
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Background
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain) . The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.
NCBI Gene ID
1761
Swiss Prot
Q9Y5R6
Accession Number
Q9Y5R6
Host
Rabbit
Reactivity
Human
Immunogen
This DMRT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-322 amino acids from the C-terminal region of human DMRT1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
39 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
DMRT1
NCBI Official Name
Doublesex- and mab-3-related transcription factor 1
NCBI Organism
Homo sapiens
Background Reference 01
Kang, J.U., et al. Int. J. Oncol. 37 (2) :327-335 (2010)
Background Reference 02
Turnbull, C., et al. Nat. Genet. 42 (7) :604-607 (2010)
Background Reference 03
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 04
Krentz, A.D., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (52) :22323-22328 (2009)
Other Product Names
Doublesex- and mab-3-related transcription factor 1, DM domain expressed in testis protein 1, DMRT1, DMT1
Tested Applications
WB
Protein ID
83305820
Physical Properties
Liquid

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