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PCBP1 Antibody

CAT: 0223-60-150Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-150Size:400 µL
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Background
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly (rC) -binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
NCBI Gene ID
5093
Swiss Prot
Q15365
Accession Number
Q15365
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PCBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-217 amino acids from the Central region of human PCBP1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Rabbit
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
37 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PCBP1
NCBI Official Name
Poly (rC) -binding protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Cloke, B., et al. Endocrinology 151 (8) :3954-3964 (2010)
Background Reference 02
Wang, H., et al. Cancer Cell 18 (1) :52-62 (2010)
Background Reference 03
Zhang, T., et al. Mol. Cancer 9, 72 (2010) :
Background Reference 04
Waggoner, S.A., et al. J. Biol. Chem. 284 (14) :9039-9049 (2009)
Other Product Names
Poly (rC) -binding protein 1, Alpha-CP1, Heterogeneous nuclear ribonucleoprotein E1, hnRNP E1, Nucleic acid-binding protein SUB23, PCBP1
Tested Applications
WB
Protein ID
42560548
Physical Properties
Liquid

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