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MRPS31 Antibody

CAT: 0223-60-091Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-091Size:400 µL
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Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. [provided by RefSeq].
NCBI Gene ID
10240
Swiss Prot
Q92665
Accession Number
Q92665
Host
Rabbit
Reactivity
Human
Immunogen
This MRPS31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 219-247 amino acids from the Central region of human MRPS31.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
45 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MRPS31
NCBI Official Name
28S ribosomal protein S31, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Dunham, A., et al. Nature 428 (6982) :522-528 (2004)
Background Reference 02
Zhang, Z., et al. Genomics 81 (5) :468-480 (2003)
Background Reference 03
Tchernev, V.T., et al. Mol. Med. 8 (1) :56-64 (2002)
Background Reference 04
Cavdar Koc, E., et al. J. Biol. Chem. 276 (22) :19363-19374 (2001)
Other Product Names
28S ribosomal protein S31, mitochondrial, MRP-S31, S31mt, Imogen 38, MRPS31, IMOGN38
Tested Applications
WB
Protein ID
93186129
Physical Properties
Liquid

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