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Mouse Il12b Antibody

CAT: 0223-60-064Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-064Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC (By similarity) . Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
NCBI Gene ID
16160
Swiss Prot
P43432
Accession Number
P43432
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Il12b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-222 amino acids from the Central region of mouse Il12b.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
38 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Il12b
NCBI Official Name
Interleukin-12 subunit beta
NCBI Organism
Mus musculus
Background Reference 01
Kagami, S., et al. J. Immunol. 185 (9) :5453-5462 (2010)
Background Reference 02
Wozniak, T.M., et al. Infect. Immun. 78 (10) :4187-4194 (2010)
Background Reference 03
Lindsay, R.W., et al. J. Immunol. 185 (3) :1513-1521 (2010)
Background Reference 04
Marshall, H.D., et al. J. Immunol. 185 (3) :1419-1428 (2010)
Other Product Names
Interleukin-12 subunit beta, IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, IL-12 subunit p40, Il12b
Tested Applications
WB
Physical Properties
Liquid

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