SERPINI2 Antibody

• Background:

  The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.

• NCBI Gene ID:

  5276

• Swiss Prot:

  O75830

• Accession Number:

  O75830

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SERPINI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 375-401 amino acids from the C-terminal region of human SERPINI2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  46 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SERPINI2

• NCBI Official Name:

  Serpin I2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Liu, C.Y., et al. Carcinogenesis 31 (7) :1259-1263 (2010)

• Background Reference 02:

  Lim, J., et al. Cell 125 (4) :801-814 (2006)

• Background Reference 03:

  Chang, W.S., et al. Genes Chromosomes Cancer 29 (3) :240-255 (2000)

• Background Reference 04:

  Xiao, G., et al. Proc. Natl. Acad. Sci. U.S.A. 96 (7) :3700-3705 (1999)

• Other Product Names:

  Serpin I2, Myoepithelium-derived serine protease inhibitor, Pancpin, Pancreas-specific protein TSA2004, Peptidase inhibitor 14, PI-14, SERPINI2, MEPI, PI14

• Tested Applications:

  WB

• Physical Properties:

  Liquid