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RNF14 Antibody

CAT: 0223-59-350Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-350Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.
NCBI Gene ID
9604
Swiss Prot
Q9UBS8
Accession Number
Q9UBS8
Host
Rabbit
Reactivity
Human
Immunogen
This RNF14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the C-terminal region of human RNF14.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RNF14
NCBI Official Name
E3 ubiquitin-protein ligase RNF14
NCBI Organism
Homo sapiens
Background Reference 01
Xu, K., et al. Cancer Cell 15 (4) :270-282 (2009)
Background Reference 02
Lan, K.C., et al. Fertil. Steril. 89 (5 SUPPL), 1397-1405 (2008) :
Background Reference 03
Kikuchi, H., et al. Carcinogenesis 28 (8) :1752-1758 (2007)
Background Reference 04
Yang, Z., et al. Endocrinology 148 (3) :1340-1349 (2007)
Other Product Names
E3 ubiquitin-protein ligase RNF14, 632-, Androgen receptor-associated protein 54, HFB30, RING finger protein 14, Triad2 protein, RNF14, ARA54
Tested Applications
WB
Protein ID
17380293
Physical Properties
Liquid

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