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MYH7 Antibody

CAT: 0223-59-342Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-342Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.
NCBI Gene ID
4625
Swiss Prot
P12883
Accession Number
P12883
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This MYH7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-211 amino acids from the N-terminal region of human MYH7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
223 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MYH7
NCBI Official Name
Myosin-7
NCBI Organism
Homo sapiens
Background Reference 01
Millat, G., et al. Clin. Chim. Acta 411 (23-24), 1983-1991 (2010) :
Background Reference 02
Eijgelsheim, M., et al. Hum. Mol. Genet. 19 (19) :3885-3894 (2010)
Background Reference 03
Millat, G., et al. EurMed Genet 53 (5) :261-267 (2010)
Background Reference 04
Muelas, N., et al. Neurology 75 (8) :732-741 (2010)
Other Product Names
Myosin-7, Myosin heavy chain 7, Myosin heavy chain slow isoform, MyHC-slow, Myosin heavy chain, cardiac muscle beta isoform, MyHC-beta, MYH7, MYHCB
Tested Applications
WB
Protein ID
83304912
Physical Properties
Liquid

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