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POLR3C Antibody

CAT: 0223-59-040Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-040Size:400 µL
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Background
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.
NCBI Gene ID
10623
Swiss Prot
Q9BUI4
Accession Number
Q9BUI4
Host
Rabbit
Reactivity
Human
Immunogen
This POLR3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-230 amino acids from the Central region of human POLR3C.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
61 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
POLR3C
NCBI Official Name
DNA-directed RNA polymerase III subunit RPC3
NCBI Organism
Homo sapiens
Background Reference 01
Ablasser, A., et al. Nat. Immunol. 10 (10) :1065-1072 (2009)
Background Reference 02
Hu, P., et al. Mol. Cell. Biol. 22 (22) :8044-8055 (2002)
Background Reference 03
Kuwana, M., et al. Arthritis Rheum. 46 (10) :2742-2747 (2002)
Background Reference 04
Hsieh, Y.J., et al. Mol. Cell. Biol. 19 (11) :7697-7704 (1999)
Other Product Names
DNA-directed RNA polymerase III subunit RPC3, RNA polymerase III subunit C3, DNA-directed RNA polymerase III subunit C, RNA polymerase III 62 kDa subunit, RPC62, POLR3C
Tested Applications
WB
Protein ID
60393871
Physical Properties
Liquid

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