SGCA Antibody

• Background:

  This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  6442

• Swiss Prot:

  Q16586

• Accession Number:

  Q16586

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SGCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-266 amino acids from the Central region of human SGCA.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  43 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  SGCA

• NCBI Official Name:

  Alpha-sarcoglycan

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Mendell, J.R., et al. Ann. Neurol. 68 (5) :629-638 (2010)

• Background Reference 02:

  Fernandez, K., et al. Am. J. Pathol. 176 (1) :416-434 (2010)

• Background Reference 03:

  Klinge, L., et al. Neuromuscul. Disord. 18 (12) :934-941 (2008)

• Background Reference 04:

  Delgado-Olguin, P., et al. Biochim. Biophys. Acta 1779 (1) :74-80 (2008)

• Other Product Names:

  Alpha-sarcoglycan, Alpha-SG, 50 kDa dystrophin-associated glycoprotein, 50DAG, Adhalin, Dystroglycan-2, SGCA, ADL, DAG2

• Tested Applications:

  WB

• Physical Properties:

  Liquid