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SGCA Antibody

CAT: 0223-59-032Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-59-032Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
6442
Swiss Prot
Q16586
Accession Number
Q16586
Host
Rabbit
Reactivity
Human
Immunogen
This SGCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-266 amino acids from the Central region of human SGCA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
SGCA
NCBI Official Name
Alpha-sarcoglycan
NCBI Organism
Homo sapiens
Background Reference 01
Mendell, J.R., et al. Ann. Neurol. 68 (5) :629-638 (2010)
Background Reference 02
Fernandez, K., et al. Am. J. Pathol. 176 (1) :416-434 (2010)
Background Reference 03
Klinge, L., et al. Neuromuscul. Disord. 18 (12) :934-941 (2008)
Background Reference 04
Delgado-Olguin, P., et al. Biochim. Biophys. Acta 1779 (1) :74-80 (2008)
Other Product Names
Alpha-sarcoglycan, Alpha-SG, 50 kDa dystrophin-associated glycoprotein, 50DAG, Adhalin, Dystroglycan-2, SGCA, ADL, DAG2
Tested Applications
WB
Physical Properties
Liquid

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