SGCB Antibody

CAT: 0223-25-941Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-25-941Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SGCB is a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix.The dystrophin-glycoprotein complex (DGC) is a multisubunit protein complex that spans the sarcolemma and provides structural linkage between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. There are 3 main subcomplexes of the DGC: the cytoplasmic proteins dystrophin (DMD; MIM 300377) and syntrophin (SNTA1; MIM 601017), the alpha- and beta-dystroglycans (see MIM 128239), and the sarcoglycans (see, e.g., SGCA; MIM 600119) (Crosbie et al., 2000 [PubMed 10942431]) .
NCBI Gene ID
6443
Swiss Prot
Q16585
Accession Number
NP_000223
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SGCB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. XBL-10407 - Fetal Heart Tissue Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store SGCB antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
35 kDa
Applications Notes
SGCB antibody can be used for detection of SGCB by ELISA at 1:312500. SGCB antibody can be used for detection of SGCB by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
SGCB
NCBI Official Name
Sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
NCBI Organism
Homo sapiens
Background Reference 01
Draviam, R.A., (2006) Muscle Nerve 34 (6), 691-701.
Other Product Names
SGCB, A3b, LGMD2E, SGC
Tested Applications
ELISA, WB
Protein ID
4506913
Physical Properties
Liquid

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