Products for Research Use Only

RHO Antibody

CAT: 0223-58-850Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-850Size:400 µL
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Background
Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form, which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness.
NCBI Gene ID
6010
Swiss Prot
P08100
Accession Number
P08100
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This RHO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-339 amino acids from the C-terminal region of human RHO.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
39 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RHO
NCBI Official Name
Rhodopsin
NCBI Organism
Homo sapiens
Background Reference 01
Clark, G.R., et al. Ophthalmology 117 (11) :2169-2177 (2010)
Background Reference 02
Li, S., et al. Biochem. Biophys. Res. Commun. 401 (1) :42-47 (2010)
Background Reference 03
Pulagam, L.P., et al. J. Biol. Chem. 285 (38) :29446-29456 (2010)
Background Reference 04
Audo, I., et al. Arch. Ophthalmol. 128 (8) :1036-1045 (2010)
Other Product Names
Rhodopsin, Opsin-2, RHO, OPN2
Tested Applications
WB
Protein ID
129207
Physical Properties
Liquid